S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways

Mohd W. Nasser,Zahida Qamri,Yadwinder S. Deol,Janani Ravi,Catherine A. Powell,Prashant Trikha,Reto A. Schwendener,Xue-Feng Bai,Konstantin Shilo,Xianghong Zou,Gustavo Leone,Ronald Wolf,Stuart H. Yuspa,Ramesh K. Ganju

S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways

2012

Mohd W. Nasser
Zahida Qamri
Yadwinder S. Deol
Janani Ravi
Catherine A. Powell
Prashant Trikha
Reto A. Schwendener
Xue-Feng Bai
Konstantin Shilo
Xianghong Zou
Gustavo Leone
Ronald Wolf
Stuart H. Yuspa
Ramesh K. Ganju

A novel mouse model of breast cancer shows how a factor implicated in tissue inflammation can enhance growth and metastasis by activating proinflammatory pathways which recruit tumor-associated macrophages.

Keywords:

Inflammation
Molecular biology
Chemokine
Proinflammatory cytokine
Downregulation and upregulation
Metastasis
Cancer research
Carcinogenesis
Vascular endothelial growth factor A
Immunology
S100A7
Biology
Cancer
Breast cancer
Signal transduction
Estrogen receptor
Angiogenesis

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