The Subcommissural Organ of the Rat: An In Vivo Model of Neuron—Glia Interactions

It is established that neurotransmitters in general and serotonin (5HT) in particular have a trophic role in the maturation of the central nervous system (CNS) (Lauder 1983). This action could be mediated in part via regulation of glia since neuron—glia interactions are necessary for the maturation of both neurons and glia (Hatten and Mason 1986; Holton and Weston 1982; Le Prince et al. 1990) and since glial cells in the CNS possess receptors for neurotransmitters (Whitaker-Azmitia 1988).