SYNTHESIS OF NOVEL ALKYLAMINOHYDROXYPROPOXY COUMARIN DERIVATIVES

Coumarin molecule is used as anticoagulant. Other uses like anti-HIV, anti-tumor, antihypertensive, anti-arrhythmia, anti-osteoporosis, pain relief increase research of coumarin derivative. Perkin discovered a synthetic method of coumarin and opened the door in synthetic research. Now a days there are so many methods are use to form coumarin. Warfarin is a well known drug of 4-hydroxy coumarin derivative. It is consider that, propranolol drug act as a lead molecule of â-blocker. Alkylaminohydroxypropoxy side chain is responsible for â-blocking activity in propranolol. Hence synthesis and it’s characterization of antihypertensive coumarin derivative was our main target.