Measurement and Correlation of Solubility of Gatifloxacin in 12 Pure Solvents from 273.15 K to 318.15 K

The solubility of gatifloxacin in 12 pure organic solvents (methanol, ethanol, n-propanol, n-butanol, isopropanol, acetone, butanone, acetonitrile, 1,4-dioxane, ethyl acetate, toluene, and N,N-dimethylformamide (DMF)) was obtained at temperatures from 273.15 K to 318.15 K. The results show that the solubility of gatifloxacin in those 12 pure solvents increases with increasing temperature. At a given temperature range, they gradually decrease in the following order: ethyl acetate (6.789 × 10–3, 298.15 K) > DMF (5.657 × 10–3, 298.15 K) > butanone (3.488 × 10–3, 298.15 K) > acetonitrile (2.811 × 10–3, 298.15 K) > n-butanol (2.246 × 10–3, 298.15 K) > acetone (1.766 × 10–3, 298.15 K) > 1,4-dioxane (1.288 × 10–3, 298.15 K) > n-propanol (0.922 × 10–3, 298.15 K) > ethanol (0.698 × 10–3, 298.15 K) > methanol (0.531 × 10–3, 298.15 K) > isopropanol (0.401 × 10–3, 298.15 K) > toluene (0.261 × 10–3, 298.15 K). The (KAT-LSER) model was applied to analyze the effect of the solute–solvent intermolecular interactions on t...