Development of a novel glycated protein-based fibrosis prediction score for determination of significant liver fibrosis in HCV-infected patients, a preliminary study.

BACKGROUND The current study aimed to investigate the diagnostic value of glycated albumin, glycated hemoglobin and a number of routine biomarkers as noninvasive indicators of liver fibrosis in chronic hepatitis C (CHC) patients. METHODS One hundred patients with CHC were subjected to full medical history and examination, in addition to ultrasound guided liver biopsy and histopathological examination for assessment of liver fibrosis stage. Glycated albumin (GA) and HbA1c values, GA/HbA1c ratio, liver function tests, complete blood count and AFP were determined. A novel noninvasive index, dubbed Fibrosis Prediction Score (FPS), was selected for predicting significant liver fibrosis based on total bilirubin, glycated albumin, platelet count, age and AFP. A validation study for FPS was applied on archival data which include 66 diabetics' patients. RESULTS The FPS had AUC of 0.92 for classification of patients with significant fibrosis with 81% sensitivity and 95 % specificity. The AUCs of FPS in predicting advanced fibrosis and cirrhosis were 0.86 and 0.82, respectively. Comparison of AST -to- Platelet ratio index (APRI) and FIB-4 with FPS indicated increased sensitivity and specificity of FPS over APRI and FIB4 in both significant and advanced fibrosis. IN CONCLUSION FPS has a good sensitivity and specificity for prediction of significant and advanced liver fibrosis in chronic hepatitis C patients. This article is protected by copyright. All rights reserved.