Study on the chemical composition of triterpenoid from the fruit of Buddleja lindleyana and their neuroprotective activitiy

Objective: To study the chemical composition of triterpenoid from the fruit of Buddleja lindleyana.Methods: The chemical components were isolated by chromatography.The structures were identified by spectral data.The neuroprotective activity of these compounds were evaluated by using MPP+ induced injury in PC12 cells.Results:3 compounds were separated and identified as oleanane,α-L-msnnopyranoside derive(1),13,28-epoxy-3β,23-dihydroxy-11-oleanene(2),3,23,28-trihydroxyolean-11,13(18)-diene(3).Compounds 1~3 showed obviously neuroprotective activity.Conclusion: The data of compound(1) is reported for the first time.The neuroprotective activities of compounds 1,2,3 are reported for the first time.