Synthesis and Biological Evaluation of 1-Cyclohexyl Substituted 3-Aminopyrrolidine Derivatives as CC Chemokine Receptor 2 (CCR2) Antagonists

Over the last decade extensive preclinical studies, including various animal disease models, have uncovered a role of CCR2 in the inflammation-related diseases such as rheuma-toid arthritis, multiple sclerosis, atherosclerosis, chronic obstruc-tive pulmonary disease (COPD) and type 2 diabetes mellitus.