Amplification of HBB gene involved in Beta-thalassemia

Beta-thalassemia is a genetic recessive disorder which impairs the hemoglobin production. It is mainly caused due to the reduced -chain production of hemoglobin. In the world, around 8% of people are affected due to this disease. At present, there is no cure for diseases. In this study, we discussed the classification of thalassemia, its causes, the risk factors associated with the diseases. We have also discussed mutants affecting the translation of -globin mRNA. Further, we enumerated the isolation of genomic DNA and amplification of the HBB1 gene from minor thalassemia patients.