Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.

Katrin Groebke Zbinden,Lilli Anselm,David Banner,Jörg Benz,Francesca Blasco,Guillaume Décoret,Jacques Himber,Bernd Kuhn,Narendra Panday,Fabienne Ricklin,Philippe Risch,Daniel Schlatter,Martin Stahl,Stefan Thomi,Robert Unger,Wolfgang Haap

Design of Novel Aminopyrrolidine Factor Xa Inhibitors from a Screening Hit.

2009

Katrin Groebke Zbinden
Lilli Anselm
David Banner
Jörg Benz
Francesca Blasco
Guillaume Décoret
Jacques Himber
Bernd Kuhn
Narendra Panday
Fabienne Ricklin
Philippe Risch
Daniel Schlatter
Martin Stahl
Stefan Thomi
Robert Unger
Wolfgang Haap

Starting from a hit identified by focused screening, 3-aminopyrrolidine factor Xa inhibitors were designed. The binding mode as determined by X-ray structural analysis as well as the pharmacokinetic behaviour of selected compounds is discussed.

Keywords:

Factor Xa Inhibitor
Organic chemistry
Antithrombotic Agent
Coagulation Factor Xa
Molecular model
Biochemistry
Stereochemistry
Chemistry
blood clotting
benzene derivatives
x ray analysis
computer aid

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