Novel A,B,E-Ring-Modified Camptothecins Displaying High Lipophilicity and Markedly Improved Human Blood Stabilities

David Bom,Dennis P. Curran,Ashok J. Chavan,Stefan Kruszewski,Stephen G. Zimmer,Kimberly A. Fraley,Thomas G. Burke

Novel A,B,E-Ring-Modified Camptothecins Displaying High Lipophilicity and Markedly Improved Human Blood Stabilities

1999

David Bom
Dennis P. Curran
Ashok J. Chavan
Stefan Kruszewski
Stephen G. Zimmer
Kimberly A. Fraley
Thomas G. Burke

Author(s): Bom, D; Du, W; Garbarda, A; Curran, DP; Chavan, AJ; Kruszewski, S; Zimmer, SG; Fraley, KA; Bingcang, AL; Wallace, VP; Tromberg, BJ; Burke, TG

Keywords:

Lipophilicity
Biochemistry
Chemistry
Stereochemistry
Lactone
Enzyme inhibitor
Chemical synthesis
Amine gas treating
Topoisomerase
Lactam
Chemical modification

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