Molecular mechanism of G2 phase cell cycle arrest in tumor cells

The formation and progression of tumor is inseparable from the changes of cell cycle regulatory proteins. The G2-M period block effect of tumor cells is especially important in slowing the growth of tumor and improving the curative effect. DNA damage receptor, signal transduction factor and effectors are the classical pathways to mediate G2 phase arrest of tumor cells, and have the potential to be new targets for tumor therapy. Key words: DNA damage; Cell cycle; Neoplasms