Therapeutic Efficacy of Subcutaneous and Intraperitoneal Injections of a Single Dose of Human Umbilical Mesenchymal Stem Cells in Acute and Chronic Colitis in a Mouse Model

Purpose Intraperitoneal (IP) injection of mesenchymal stem cells (MSCs) has been reported to treat colitis in mice. Complications such as abdominal organ injury and infection are significant concerns. We studied a single injection of human umbilical cord MSCs (hUCMSCs) via the subcutaneous (SC) and IP routes in mice with colitis.