Role of Interferon‐γ in Counteracting the Suppressive Effects of Transforming Growth Factor‐β2 and Glucocorticoids on the Production of Tumor Necrosis Factor‐α

The suppression in LPS-induced production of TNF-α caused by TGF-β2, dexamethasone, and cortisol could be reversed by addition of rPolFN-γ. These data show that alveolar macrophages can be effectively primed by rPolFN-γ even in the presence of moderately suppressive doses of TGF-β2 and antiinflammatory steroids