GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells

Zhenzhen Hu,Jun Du,Ling Yang,Yichao Zhu,Yu Yang,Datong Zheng,Akimasa Someya,Luo Gu,Xiang Lu

GEP100/Arf6 Is Required for Epidermal Growth Factor-Induced ERK/Rac1 Signaling and Cell Migration in Human Hepatoma HepG2 Cells

2012

Zhenzhen Hu
Jun Du
Ling Yang
Yichao Zhu
Yu Yang
Datong Zheng
Akimasa Someya
Luo Gu
Xiang Lu

Background Epidermal growth factor (EGF) signaling is implicated in the invasion and metastasis of hepatoma cells. However, the signaling pathways for EGF-induced motility of hepatoma cells remain undefined.

Keywords:

Autocrine signalling
Epidermal growth factor
RAC1
MAPK/ERK pathway
Transfection
Cell biology
Signal transduction
Cancer research
Motility
Cell migration
Biology

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