Synthesis, antimicrobial and antitubercular activity of some cyclohexenone and indazole derivatives

The series of compounds 6-carbethoxy-5-aryl-3-(3,5-dibromo-4-methoxy phenyl)-2-cyclohexenones 2a-j are obtained from the (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones 1a-j by Michael addition of ethyl acetoacetate, followed by internal Claisen condensation. Reaction of 2a-j with hydrazine hydrate afforded the corresponding 6-(3,5-dibromo-4-methoxyphenyl)-4-aryl-2,3a,4,5-tetrahydro-3H-indazol-3-ones 3a-j. The constitution of all the synthesized compounds have been established by elemental analyses, IR, 1 H NMR and mass spectral data. All the compounds have been screened for their antimicrobial activities and compounds 2a-j have been tested for antitubercular activity.