Anti-inflammatory, Analgesic and Antiparkinsonism Activities of Some Novel Pyridazine Derivatives

Six compounds of pyridazine derivatives 1-6 have been pharmacological screening. The pharmacological screening showed that many of these compounds have a good anti-inflammatory, analgesic and antiparkinsonism activities comparable to reference drugs. The compounds 1a, 1b, 1c, 2a, 2b, and 5 were found more potent than Prednisolone (prednisolone) ® and the inhibition of plasma PGE2 for these compounds were found more potent than prednisolone (prednisolone) ® . The analgesic activities of all compounds were more potent than Valdecoxib (Bextra) ® . Also, the compounds 1b, 2a, and 3b are the most potent antiparkinsonism agent comparable to Benzatropine (Benzotropene) ® . The pharmacological properties are reported. (Journal of American Science 2010;6(7):353-357). (ISSN: 1545-1003).