A 1,1′-biuracil from Epidermidibacterium keratini EPI-7 shows anti-aging effects on human dermal fibroblasts

Our previous study we isolated novel bacterial stain, Epidermidibacterium keratini, called EPI-7T from skin samples. Repeated column separation yielded one new pyrimidine compound, 1,1′-biuracil, from EPI-7T culture solutions grown in R2A medium. Its chemical structure was determined based on spectroscopic data, IR, FAB/MS, and NMR. And 1,1′-biuracil and EPI-7T culture solutions showed regulating effects of anti-aging associated mRNA expressions in UV-irradiated fibroblasts without toxicity in Hs68 cells. These results demonstrates the cosmetic potential of 1,1′-biuracil and EPI-7T as anti-aging agents.