Measurement of activation products generated in the [18F]FDG production by a 9.6 MeV cyclotron

Abstract Gamma-ray spectrometry was used for the identification and quantification of the activation products induced during the production of [ 18 F]FDG in a cyclotron with a beam of 9.6 MeV protons, a silver target and Havar entrance window. Samples of the irradiated water collected before and after the 18 F separation, and of the final product [ 18 F]FDG were measured in the particular conditions of a beam current of 45 μA and an irradiation time of 25–30 min The radionuclides 52 Mn, 55 Co, 56 Co, 57 Co, 58 Co, 95 Tc, 96 Tc, and 109 Cd were identified in the irradiated water samples, but not detected in the final [ 18 ]FDG product. The requirements for the transport of the recovered enriched water are also discussed.