A simple nanoplasmonic sensor with microliter sample handling

RESULTS: The efficiency in liquid exchange is shown by injecting 5 μL glycerol containing solutions of increasing concentration leading to exchange times below one second (Fig. 2a). Orthogonal (material specific) surface functionalization as shown in a previous study [2] is performed under constant flow conditions (5 μL/min) using a total volume of 50 μL (Fig. 2b). This platform with bioactive areas on the gold disks can be used for specific binding of analytes to the sensitive gold regions only (Fig. 2c).