BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141

Yukun Liu,Ran Zhao,Yanmei Wei,Mengna Li,Heran Wang,Weihong Niu,Yao Zhou,Yuanzheng Qiu,Songqing Fan,Yihao Zhan,Wei Xiong,Yanhong Zhou,Xiaoling Li,Zheng Li,Guiyuan Li,Ming Zhou

BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141

2018

Yukun Liu
Ran Zhao
Yanmei Wei
Mengna Li
Heran Wang
Weihong Niu
Yao Zhou
Yuanzheng Qiu
Songqing Fan
Yihao Zhan
Wei Xiong
Yanhong Zhou
Xiaoling Li
Zheng Li
Guiyuan Li
Ming Zhou

Background miR-141 is up-regulated and plays crucial roles in nasopharyngeal carcinoma (NPC). However, the molecular mechanism underlying the dysregulation of miR-141 is still obscure.

Keywords:

PI3K/AKT/mTOR pathway
Biology
Cancer research
Apoptosis
Nasopharyngeal carcinoma
Cell growth
molecular mechanism
tumor growth
Double negative

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