Application and possible mechanisms of combining LLLT (low level laser therapy), infrared hyperthermia and ionizing radiation in the treatment of cancer
2014
Benefit of concomitant infrared hyperthermia and low level laser therapy and ionizing
radiation is evaluated in this study. The purpose/objectives: presentation with locally
advanced bulky superficial tumors is clinically challenging. To enhance the efficacy of
chemotherapy and IMRT (intensity-modulated radiation therapy) and/or electron beam
therapy we have developed an inexpensive and clinically effective infrared hyperthermia
approach that combines black-body infrared radiation with halogen spectrum radiation and
discrete wave length infrared clinical lasers LLLT. The goal is to produce a composite
spectrum extending from the far infrared to near infrared and portions of the visible
spectrum with discrete penetrating wavelengths generated by the clinical infrared lasers
with frequencies of 810 nm and/or 830 nm. The composite spectrum from these sources is
applied before and after radiation therapy. We monitor the surface and in some cases
deeper temperatures with thermal probes, but use an array of surface probes as the limiting
safe thermal constraint in patient treatment while at the same time maximizing infrared
entry to deeper tissue layers. Fever-grade infrared hyperthermia is produced in the first
centimeters while non-thermal infrared effects act at deeper tissue layers. The combination
of these effects with ionizing radiation leads to improved tumor control in many cancers.
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