Metal-free chemo- and regioselective acylation of pyridine derivatives with alcohols in water
2017
Abstract A straightforward acylaltion of pyridine derivatives has been developed using K 2 S 2 O 8 as the oxidant and water as a green solvent. The corresponding 2-acylpyridines were synthesized with high chemo- and regioselectivity in good to high yields. This efficient and practical method could serve as a new tool for the convenient synthesis of 2-benzoylpyridines of interest for future pharmaceutical and chemical applications.
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