Hypoxia in oral squamous cell carcinoma: A breath of fresh air in cancer research?

It is an established fact that solid tumors are deprived of oxygen, to varying extents due to aberrant vascular function. The hypoxia caused, influences the properties of tumors from proliferation and angiogenesis to radiation and chemotherapy resistance. This paper is an attempt to review the explosion in research on hypoxia inducible factor in oral squamous cell carcinoma.