Flavonoid-rich Fractions from Clerodendrum Volubile and Vernonia Amygdalina Extenuates Arsenic-invoked Hepato-renal toxicities via Augmentation of the Antioxidant system in Rats
2021
Abstract Arsenicosis remains a global health concern due to devastating health effects. Clerodendrum volubile and vernonia amygdalina have tremendous bioactivities against oxidative stress-related diseases. The study, therefore, appraised the effects of flavonoids fractions from C. volubile and V. amygdalina (FCV and FVA respectively) against arsenic-induced oxidative stress in rats. Thirty male Wistar rats (120 ± 10 g) were divided into six groups of five each; Control (distilled water), arsenic alone (40 ppm sodium arsenite), arsenic + FCV (100 mg/kg), arsenic + FVA (100 mg/kg), arsenic + FCV and FVA (50 mg/kg each), and arsenic + vitamin C (100 mg/kg). The treatment commenced after four-week long arsenic exposure and lasted another four weeks. Blood, liver and kidneys of the rats were collected after sacrifice following an overnight fast. Arsenic caused significant (p
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