Prevalence of non albicans Candida in diabetic subjects and its extracellular enzymatic profiles

Aims: Epidemiology of Candidiosis their prevalence, identification and evaluation of extra cellular enzymes patterns in non albicans Candia group from the oral washings of diabetic subjects. Materials and Methods: A total of 125 oral samples were collected and analyzed. The Candiad species were identified by means of morphological and by molecular methods. The production of virulence factors assessed by using standard protocols. Results: Total of 70 different yeast like fungal strains were isolated and identified. The selected 6 virulence factors were investigated and compared critically among the NAC species. The overall observations were indicating that the virulence factors are fluctuated randomly with in the strains tested. Maximum extent of the virulence factors were reported as Phospholipase [Candida parapsilosis], protease [Candida tropicalis-2, Candida parapsilosis], Haemolysin [Candida tropicalis-3], Coagulase [Candida tropicalis-3], and Biofilm formation [Candida parapsilosis] respectively. Conclusions: In the present study we focused mainly on NAC species and their credible factors responsible for the progression of infections in diabetic subjects. Keywords: Virulence factors, Non albicans Candida, Hydrolytic enzymes, Diabetic subjects, Oral candidiasis.