Pharmacological Activities Of Two New 8-Hydroxy quinoline Derivatives

Banacer Himmi,My Abbas Faouzi,M.Akioud,Said Kitane,Abdelhamid Eddaif,M. Soufiaoui,S.Ghoulidi,Abdelmejid Bahloul,Et A.Sebban,Y. Cherrah

Pharmacological Activities Of Two New 8-Hydroxy quinoline Derivatives

2007

Banacer Himmi
My Abbas Faouzi
M.Akioud
Said Kitane
Abdelhamid Eddaif
M. Soufiaoui
S.Ghoulidi
Abdelmejid Bahloul
Et A.Sebban
Y. Cherrah

In thiswork, the acute experimental toxicity of two new8-hydroxyquinoline derivatives products was evaluated following oral administration in mice(IopsOfa). The LD50obtainedwere 283.70mg/kg for(2a) and >3000mg/ kg for(2b). Their in vitro antibacterial and antifungal activities were evaluated against reference strains.

Keywords:

Oral administration
Pharmacology
Acute toxicity
Antifungal
Antimicrobial
Quinoline
Chemistry
Toxicity
In vitro

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