Antiulcer and antiadipogenic acitities of carotenoid and anthocyanin extracts from color-fleshed sweet potato

Sweet potato (Ipomoea batatas Lam.) is an important industrial crop and source of food that contains useful dietary fiber and vitamins. Recently, orange- and purple- fleshed varieties have been shed light on owing to their healthful components, carotenoids and anthocyanins, respectively. In this study, we examined the protective effect on the HCl/EtOH-induced gastric ulcer mice model and anti-oxidant activities. Each carotenoid and anthocyanin extract from orange- and purple- fleshed sweet potatoes was evaluated for gastro-protection in mice using a HCl/EtOH-induced ulcer model. Efficacy was assessed by determination of mean ulcer size, and protection rate. Oral administration of the carotenoid and anthocyanin extract (100 mg/kg) protected against gastric lesions by 78.1% and 60.7%, as compared to a positive control, sucralfate (77.5%) in this ulcer model, respectively. This finding suggests that the significant gastroprotective activity could be mediated by its antioxidant activity which was evaluated by using different antioxidant assays including DPPH, ABTS, and FRAP. In addition, anti-adipogenic activity of these extracts was also evaluated. As a result, carotenoid extract suppressed the differentiation of 3T3-L1 preadipocytes to adipocytes. Acknowledgements: This work was supported by grants from the Next-Generation BioGreen 21 Program (SSAC, grant#: No. PJ009506 to H-S Lee and M-J Ahn), the Rural Development Administration of Republic of Korea