Structure–activity relationships of Halichondrin B analogues: modifications at C.30–C.38

Yuan Wang,Greg J. Habgood,William J. Christ,Yoshito Kishi,Bruce A. Littlefield,Melvin J. Yu

Structure–activity relationships of Halichondrin B analogues: modifications at C.30–C.38

2000

Yuan Wang
Greg J. Habgood
William J. Christ
Yoshito Kishi
Bruce A. Littlefield
Melvin J. Yu

Abstract Structurally simplified analogues of halichondrin B were prepared by total synthesis and found to retain potent cell growth inhibitory activity in vitro.

Keywords:

Total synthesis
Stereochemistry
Halichondrin B
Structure–activity relationship
Biochemistry
Chemistry
Cell growth
Organic chemistry
In vitro

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