Design and synthesis of 4-arylpiperidinyl amide and N-arylpiperdin-3-yl-cyclopropane carboxamide derivatives as novel melatonin receptor ligands

Abstract Two series of 4-arylpiperidinyl amide and N -arylpiperdin-3-yl-cyclopropane carboxamide derivatives exhibiting diverse functionality at rat MT 1 and MT 2 receptors are reported. Compounds 11f and 18b (MT 1 /MT 2 agonist) have human microsomal intrinsic clearance comparable to ramelteon.