Study on the Stability of Combining Cefodizime Sodium and Omeprazole Sodium for Injection

Objective To investigate the compatible stability of cefodizime sodium and omeprazole sodium for injection without light.Methods The content of the mixture at 4 ℃,25 ℃ and 37 ℃ for 8 h were determined by HPLC method,and its external appearance and pH value were observed.Results There were no significant changes in appearance and pH value of the mixture for injection at 4 ℃ for 8 h,25 ℃ for 6 h and 37 ℃for 2 h,respectively,the variation was less than 5%.Conclusion The mixture of cefodizime sodium and omeprazole sodium for injection can be used after storing at 4 ℃ for 8 h,25 ℃ for 6 h and 37℃ for 2 h.