Characterization and pharmacological evaluation of new pyridine analogs

Abstract Reaction of 5-ethyl pyridine-2-ethanol 1 and methane sulphonyl chloride gives corresponding sulphonate 2 ; which on condensation with p -hydroxy benzaldehyde will give 4-[2-(5-ethylpyridin-2-yl)ethoxy]benzaldehyde 3 . A series of chalcones 4a – o were prepared from 3 and substituted aromatic acetophenone. Chalcones 4a – o further react with guanidine nitrate to give a series of pyrimidines 5a – o which condense with 3,4-dichlorobenzylchloride to give amide derivatives 6a – o . Newly synthesized compounds have been examined on the basis of spectral analysis. All the compounds were screened against different gram-positive and gram-negative bacteria. Most of these compounds showed better inhibitory activity in comparison with the standard drugs.