Extensive 5'-Surveillance Guards Against Non-Canonical NAD-Caps of Nuclear mRNAs in Yeast

Yaqing Zhang,David Kuster,Tobias T. Schmidt,Daniel Kirrmaier,Gabriele Nübel,David Ibberson,Vladimir Benes,Hans Hombauer,Michael Knop,Andres Jäschke

Extensive 5'-Surveillance Guards Against Non-Canonical NAD-Caps of Nuclear mRNAs in Yeast

2020

Yaqing Zhang
David Kuster
Tobias T. Schmidt
Daniel Kirrmaier
Gabriele Nübel
David Ibberson
Vladimir Benes
Hans Hombauer
Michael Knop
Andres Jäschke

The ubiquitous redox coenzyme nicotinamide adenine dinucleotide (NAD) acts as a non-canonical cap structure on prokaryotic and eukaryotic ribonucleic acids. Here we find that in budding yeast, NAD-RNAs are abundant (>1400 species), short (

Keywords:

non canonical
Redox
NAD+ kinase
Nicotinamide adenine dinucleotide
Yeast
Genetics
Biology
budding yeast
Cofactor
Biochemistry

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