Design, Synthesis and Biological Evaluation of Ring-fused Pyrazoloamino Pyridine/Pyrimidine Derivatives as Potential FAK Inhibitors

Abstract We report herein the synthesis of novel ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors and the evaluation of pharmaceutical activity against five cancer cell lines (MDA-MB-231, BXPC-3, NCI-H1975, DU145 and 786O). Generally, the majority of compounds displayed strong anti-FAK enzymatic potencies (IC50