Oxicodone chlorhydrate preparation procedure that has less than 25 ppm of 14-hydroxycodeinone.

Procedure for preparing an oxycodone hydrochloride composition having a 14-hydroxydedendone level of less than 25 ppm based on making an oxycodone base composition having an 8,14-dihydroxy-7,8-dihydrocodeinone compound react with hydrochloric acid, with which 8,14-dihydroxy-7,8-dihydrocodeinone is converted into 14-hydroxycodeinone, and from reducing 14-hydroxycodeinone to oxycodone.