Rapid determination of telmisartan in pharmaceutical preparations and serum by linear sweep polarography

Abstract The polarographic behaviors of telmisartan (TE) are investigated in 0.8 mol/l NH 3 ·H 2 O–NH 4 Cl (pH=8.9) supporting electrolyte. The results demonstrated that the reduction peak is obtained at ca. −1.30 V, which corresponds to a catalytic hydrogen wave. Based on the catalytic hydrogen wave, a novel method has been developed for the determination of telmisartan by linear sweep polarography. Calibration curve is linear in the range 2.0×10 −7 to 3.0×10 −6  mol/l and the detection limit is 1.0×10 −7  mol/l. The proposed method is applied to the rapid determination of the telmisartan in capsule forms and biological sample without pre-separation.