Transient uterine hypercontractility causes oxidative stress in the fetal brain, sex-dependent mitochondrial abnormalities, and altered social behavior of adolescent male rat offspring

2019 
The neurodevelopmental impact of transient ischemic-hypoxemic insults is poorly understood. Here, we simulated placental ischemia-hypoxemia via oxytocin-induced uterine hypercontractility to show a profound decrease in placental perfusion/oxygenation, oxidative stress in the fetal brain, sex-dependent differences in gene expression mediating oxidative stress, and persistent upregulation of mitochondrial oxidative phosphorylation proteins in the anterior cingulate cortex along with social behavioral impairment especially in male offspring.
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