A mechanistic model to predict droplet drying history and particle shell formation in multicomponent systems

Abstract Spray drying allows tuning the physical properties of the resulting powders widely. However, targeted process design is complicated by the interplay between process characteristics and the non-ideal physical properties exhibited by multicomponent mixtures, such as pharmaceutical formulations. This work presents a mechanistic model describing the drying of single droplets. The model includes heat and mass balances, non-ideal vapour-liquid equilibria, and population balances describing the evolution of particulates within the drying droplet. The model is applied to (up to) ternary mixtures of solvents, polymers and solutes, and predicts properties of the drying droplet such as the time of shell formation and the size of the particle obtained after drying. A comparison with experimental data from single droplet drying experiments carried out at defined relative vapour saturation and temperature shows that the model can be used to predict shell formation (as well as other properties) for the systems studied here.