A General Photoinduced Electron Transfer-Directed Chemoselective Perfluoroalkylation of N,N-Dialkylhydrazones.
2016
A selective, practical and general incorporation of fluoroalkyl groups into organic frameworks is of great interest for synthesis. Herein we report the first metal-free, initiator-free, and general photochemical perfluoroalkylation of a variety of N,N-dialkylhydrazones at room temperature in the absence of any external photocatalyst. It constitutes an important advance in perfluoroalkyl radical addition to CN π bonds for the synthesis of hydrazones instead of amines. Affordable and easily available perfluoroalkyl iodides serve as effective precursors. The excellent regio-, stereo- and chemoselectivity as well as the broad substrate scope make this a very promising synthetic tool.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
1
References
0
Citations
NaN
KQI