A Comparison of the Pulmonary Bioavailability of Powder and Liquid Aerosol Formulations of Salmon Calcitonin

Andrew Clark,Mei-Chang Kuo,Stephen P. Newman,Peter Hanson Hirst,Gary R. Pitcairn,Matt Pickford

A Comparison of the Pulmonary Bioavailability of Powder and Liquid Aerosol Formulations of Salmon Calcitonin

2008

Andrew Clark
Mei-Chang Kuo
Stephen P. Newman
Peter Hanson Hirst
Gary R. Pitcairn
Matt Pickford

Purpose To compare the pulmonary pharmacokinetics and relative bioavailability of salmon calcitonin delivered as aqueous droplets, pH 6.6 and pH 4.8 with that of a spray dried powder in healthy volunteers.

Keywords:

Salmon calcitonin
Aerosol
Citric acid
Bioavailability
Chromatography
Chemistry
Pharmacokinetics
Nebulizer
dry powder
healthy volunteers
spray dried

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