Skin Surface Film Liquid as New Migration Medium for the Determination of PAHs Released from Rubber Containing Consumer Goods

ABSTRACTExposure of consumers, in particular children, to polycyclic aromatic hydrocarbons (PAHs) via contact with consumer products has been the subject of considerable public attention over the last years. Eight PAHs with a harmonized classification as carcinogen 1B, according to the Regulation EC No 1272/2008 on classification, labeling and packaging of substances and mixtures, have been identified in plastic and rubber contained in some consumer articles, such as toys, bicycle grips or sporting goods. These constitute a potential source for dermal, or even oral, exposure. Concerning the former, it is desirable to develop easy and reliable methods for migration determination using simulated environments that mimic as realistically as possible the hydro-lipidic film on human skin composed of aqueous sweat and sebum.This work proposes a protocol for the determination of PAH release from rubber using a migration simulant that mimics real skin conditions. Various compositions of skin surface film liquid (S...