Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation
2015
Activation of NLRP3 inflammasome requires generation of reactive oxygen species. Here the authors show that microbial or tissue damage-derived signals activate xanthine oxidase, which serves as a critical source of reactive oxygen species for inflammasome activation in macrophages.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
56
References
119
Citations
NaN
KQI