Advances of hyaluronic acid derivatives in biopharmaceuticals delivery

Objective To summarize the preparation of hyaluronic acid derivatives and progress of its applications in biopharmaceuticals delivery recent years.Methods According to thirty-two recent relevant literatures,the preparation of hyaluronic acid derivatives and its development in genes and proteins delivery were summarized.Results The preparation methods of various derivatives by the chemical modification of hyaluronic acid and the applications of hyaluronic acid derivatives in drug delivery were reviewed.Conclusions Hyaluronic acid derivatives in drug delivery field is promising.