Human monoclonal anti-IL-21

monoclonal anti-IL-21 human or fragment thereof, wherein said monoclonal antibody or antibody fragment comprises: (a) a heavy chain region comprising: (i) a CDR1 of the variable heavy chain region comprising SEQ ID NO: 31; (Ii) a CDR2 of the heavy chain variable region comprising SEQ ID NO: 33; and (iii) a CDR3 of the variable heavy chain region comprising SEQ ID NO: 35; and (b) a light chain region comprising: (i) a CDR1 of light chain variable region comprising SEQ ID NO: 39; (Ii) a CDR2 of the light chain variable region comprising SEQ ID NO: 41; and (iii) a CDR3 of the variable light chain region comprising SEQ ID NO: 43.