Total Synthesis of Galanthamine and Lycoramine Featuring an Early-Stage C–C and a Late-Stage Dehydrogenation via C–H Activation
2020
Herein, we report a novel strategy toward galanthamine and lycoramine. The concise synthesis was enabled by a Rh-catalyzed gram-scale C–C activation for the tetracyclic carbon framework and a regioselective Pd-catalyzed C–H activation for double-bond introduction. An aqueous-phase Beckmann rearrangement was performed for nitrogen atom insertion. Galanthamine and lycoramine were completed in 11 and 10 steps, respectively.
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