Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.

Stella Koutros,Gabriella Andreotti,Sonja I. Berndt,Kathryn Hughes Barry,Jay H. Lubin,Jane A. Hoppin,Freya Kamel,Dale P. Sandler,Laurie Burdette,Jeffrey Yuenger,Meredith Yeager,Michael C. R. Alavanja,Laura E. Beane Freeman

Xenobiotic-metabolizing gene variants, pesticide use, and the risk of prostate cancer.

2011

Stella Koutros
Gabriella Andreotti
Sonja I. Berndt
Kathryn Hughes Barry
Jay H. Lubin
Jane A. Hoppin
Freya Kamel
Dale P. Sandler
Laurie Burdette
Jeffrey Yuenger
Meredith Yeager
Michael C. R. Alavanja
Laura E. Beane Freeman

BackgroundTo explore associations with prostate cancer and farming, it is important to investigate the relationship between pesticide use and single nucleotide polymorphisms (SNPs) in xenobiotic metabolic enzyme (XME) genes.ObectiveWe evaluated pesticide–SNP interactions between 45 pesticides and 19

Keywords:

Glutamate–cysteine ligase
Genetics
Prostate cancer
Pesticide
Xenobiotic
Gene
Single-nucleotide polymorphism
Allele
Biology
metabolic enzymes
pesticide use

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