Synthesis and Biophysical Studies of Oligonucleotides Containing Hydroxamate Linkages.

Abstract Novel oligonucleotide dimers containing hydroxamate linkages ( 15 and 16 ) were synthesized, incorporated into oligonucleotide sequences and studied for their hybridization properties with complementary DNA and RNA targets. The modified oligonucleotides showed similar binding properties and enhanced resistance to exonucleases compared to natural oligonucleotides.