Using cytokine antibody arrays to elucidate complex cytokine networks in the hallmarks of cancer

I has been long known that cytokines play important role in cancer initiation, development and progression. Until recently, the lack of suitable high-content and high-throughput approaches has hindered progress in understanding the role of complex cytokine networks in cancer. Since their introduction in 2001, cytokine antibody arrays, which have the ability to detect hundreds of cytokines simultaneously in highly sensitive, high-throughput format, significant advances have been made in our understanding of the role of tumor-stromal interactions and chronic inflammation in tumorigenesis, angiogenesis and metastasis, as well as the elucidation of several cytokine-driven mechanisms of cancer drug resistance in tumor cells. This presentation will discuss cytokine antibody array technologies and their recent contributions toward a better understanding of the mechanisms of cancer hallmarks. Ruo-Pan Huang, J Clin Cell Immunol 2013, 4:5 http://dx.doi.org/10.4172/2155-9899.S1.013