Joint analysis of non-concurrent magnetic resonance imaging and diffuse optical tomography of breast cancer
2007
We have developed a novel method for combining non-concurrent MR and DOT data, which integrates advanced
multimodal registration and segmentation algorithms within a well-defined workflow. The method requires little user
interaction, is computationally efficient for practical applications, and enables joint MR/DOT analysis. The method
presents additional advantages: More flexibility than integrated MR/DOT imaging systems, The ability to independently
develop a standalone DOT system without the stringent limitations imposed by the MRI device environment, Enhancement
of sensitivity and specificity for breast tumor detection, Combined analysis of structural and functional data,
Enhancement of DOT data reconstruction through the use of MR-derived a priori structural information. We have
conducted an initial patient study which asks an important question: how can functional information on a tumor
obtained from DOT data be combined with the anatomy of that tumor derived from MRI data? The study confirms that
tumor areas in the patient breasts exhibit significantly higher total hemoglobin concentration (THC) than their
surroundings. The results show significance in intra-patient THC variations, and justify the use of our normalized
difference measure defined as the distance from the average THC inside the breast, to the average THC inside the tumor
volume in terms of the THC standard deviation inside the breast. This method contributes to the long-term goal of
enabling standardized direct comparison of MRI and DOT and facilitating validation of DOT imaging methods in
clinical studies.
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