Oxidised Low Density Lipoproteins

The evidence for the oxidative modification of low density lipoprotein (LDL) and its subsequent recognition by the scavenger receptors on macrophages in vitro is clear. The presence of oxidatively modified LDL in atherosclerotic lesions is well-recognised. However, the mechanism whereby LDL becomes oxidised in vivo is yet to be clarified. New case control studies and cross-sectional random surveys in several European countries suggest a role for dietary antioxidants in protecting LDL from oxidation.