Influencia endocrina y paracrina sobre la adipogénesis

Current scientific information on the mechanisms of adipocyte development was reviewed. In vitro and in vivo studies (different mesodermal stem cell lines with adipogenic potential) were quantified to assess the influence of the most representative substances with hormonal (Insuline, insuline-like growth factor, glucocorticoids, triiodothyronine and cAMP) and parahormonal (GFs and TNFα) activity on both the adipocyte differentiation and the changes on recruitment/proliferative pattern in the mature cell. The results of this quest showed that there were more inductor agents (66.7%) than inhibitors (33.3%) to produce adipocyte differentiation. PPARγ2 was the most active transcriptional factor involved in promoting adipogenesis and TNFα to inhibit this effect. Trough the logic analysis of these molecular interactions it can be obtained the biochemical and physiological basis for the pharmacologic designing of antiobesity compounds that may act on specifics cellular structures linked with adipogenesis; additionally, the clinicians will be able to enlarge their knowledge on the obesity pathophysiology and on the pharmacodynamics of the new drugs used for treating adipose mass excess. Key wor Key wor Key wor Key wor